proteoglycans and angiogenic growth factors

INTERACTION OF ANGIOGENIC GROWTH FACTORS WITH ENDOTHELIAL CELL HEPARAN SULFATE PROTEOGLYCANS

IMPLICATIONS FOR THE DEVELOPMENT OF ANGIOSTATIC COMPOUNDS.

Marco Presta and Marco Rusnati

Unit of General Pathology and Immunology, Department of Biomedical Science and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

1. INTRODUCTION

2. HEPARAN SULFATE PROTEOGLYCANS

Classification
Synthesis
Structure
Cell association of HSPGs
Endothelium and HSPGs

3. INTERACTION OF ANGIOGENIC GROWTH FACTORS WITH HEPARIN/HS

An overview
Molecular basis of growth factor-heparin/HS interaction
Interaction of angiogenic growth factors with extracellular matrix
HSPGs mediate the binding of angiogenic growth factors to tyrosine-kinase receptors

4. GROWTH FACTOR-HEPARIN INTERACTION: A TARGET FOR ANGIOGENESIS INHIBITORS

Natural inhibitors of angiogenesis

Protamine.
Chemokines.
Tecogalan sodium.
alpha₂-Macroglobulin.

Synthetic inhibitors of angiogenesis

Suramin derivatives.
Pentosan polysulfate.
Miscellanea.

5. CONCLUDING REMARKS

6. REFERENCES