ERYTHROPOIETIN AS AN ANGIOGENIC FACTOR 

 

D. Ribatti, A. Vacca, A.M. Roccaro, E. Crivellato, and Marco Presta

Institute of Anatomy, Histology and Embryology [D.R.] and Department of Biomedical Sciences and Human Oncology [A.V., A.M.R.], University of Bari, Piazza G. Cesare 11, 70124 Bari; Univerity of Udine Medical School [E.C.]; Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, via Valsabbina 19, 25123 Brescia, Italy [M.P.].
 

 
 

 

Epo Stimulates angiogenesis in the chik embryo CAM
 
 

Macroscopic and histologic appearance of CAMs treated with Epo-adsorbed implants (left) or control implants (right)
 
 



Back to: Presta's lab

 

 ABSTRACT

Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal transduction pathway to perform many other functions. New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions.

 

European Journal of Clinical Investigation. 2003;33:891-896.

 

 

Back to: AIRC - Special Project Angiogenesis